Qing Wang, M.D.,Ph.D.
Staff Physiatrist, Spaulding Rehabilitation Hospital
Dr. Wang's research interests and expertise revolve around the mechanisms and interventions to promote stroke recovery. She has received funding from the NIH (e.g., K12 grant and currently K08) as well as departmental grants that aim to determine molecular biological mechanisms of stroke recovery and to develop pharmacological and non-pharmacological interventions. She is the director in the Stroke Biological Recovery Laboratory at SRH.
Dr. Wang's research involves cellular, animal and clinical disciplines, aiming to bridge basic science breakthrough to bedside therapy, including genetic study, pharmacological intervention and non-invasive brain stimulation to promote stroke recovery. There are several areas of investigation that are critical to this laboratory’s core mission:
1.Develop novel interventions to promote stroke recovery. To promote functional recovery from stroke has been challenging for both scientists and clinicians. Most of the studies are focusing on single neurorestorative agents. However, the functional recovery after stroke is extremely complex and involves multiple pathways. Therefore, the combinations of agents are likely to be more effective than single agent therapy. Studies from this lab show promising results of two novel combination therapies (a. combined atorvastatin and sildenafil; b. combined transcranial direct current stimulation and methylphenidate) for improving motor recovery after stroke. This lab strives to improve the efficacy of these combination therapies and continue to develop new regimens.
2.Understand the role of inflammation in stroke recovery. There is increasing evidence showing that the neuro-inflammatory response is an important process during stroke recovery and generates both beneficial and detrimental effects. Therefore, it is important to fine tune the immune response after stroke in order to harness the benefits while avoiding detrimental effects. These researchers use serum and primary immune cells from stroke subjects, as well as rodent stroke models, to understand the role of inflammation in stroke recovery. The data show derangement in inflammatory cytokines post-stroke. Further identification of the key players will provide new insight to develop therapeutic interventions.
3.Discover biomarkers to predict recovery and to serve as surrogate to evaluate the responsiveness to therapy for developing individualized therapy. The role of blood biomarkers in stroke recovery is still unclear. These researchers have been building bio-bank database including functional outcomes and blood samples. The current bio-bank database has blood samples and data from 300 stroke patients. Ongoing research is investigating the association of brain derived neurotrophic factor with functional outcome.
Education & Training
Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho kinase attenuates endothelial-leukocyte interaction during ischemic-reperfusion injury. Vasc Med 2012;17:379-385.
Wang QM, Liao JK. ROCKs as immunomodulators of stroke. Expert Opin Ther Targets 2012;16: 1013-1025.
Wang QM, Wei Y, Zheng Y, Waeber C. Efficacy of combined atorvastatin and sildenafil in promoting recovery after ischemic stroke in mice. Am J Phys Med Rehabil 2013; 92:143-150.
Cui H, Wang QM, Fregni F. Transcranial magnetic stimulation as an assessment tool to investigate the acupuncture-induced neuroplasticity change. Alt Med Rev 2014; in press.
Qin J, Gong G, Sun S, Qi J, Zhang H, Wang Y, Wang N, Wang QM, Ji Y, Gao Y, Shi C, Yang B, Zhang Y, Song B, Xu Y. Functional recovery after transplantation of induced pluripotent stem cells in rat hemorrhagic stroke model. Neurosci Lett. 2013; 554:70-75
Zee RYL*, Wang QM*, Chasman DI, Ridker PM and Liao JK. Gene variations of ROCKs and risk of ischemic stroke: The Women’s Genome Health Study. Clinical Science. 2014; 126: 829-835.R. Zee and Q. Wang contributed equally to this study.
Wang QM, Cui H, Han SJ, Black-Schaffer R, Volz M, Lee YT, Herman S, Latif LA, Zafonte R and Fregni F. Combination of transcranial direct current stimulation and methylphenidate in subacute stroke. Neurosci Lett 2014; 569: 6-11.
Castillo SL, Morales-Quezada L, Doruk D. Rozinsky J, Coutinho L, Faria P, Persssinotti I, Wang QM, Fregni F. QEEG indexed frontal connectivity effects of transcranial pulsed current stimulation 9tPCS): a sham-controlled mechanistic trial. Neurosci Lett. 2014; 577:61-65
Li C, Wen H, Wang QM, Zhang C, Jiang L, Dou Z, Luo X, Zeng J. Exercise training inhibits the Nogo-A/NgR1/Rho-A signals in the cortical peri-infarct area in hypertensive stroke rats. AJPMR, July 1 2015. PMID 26135366
Liu X, Kenkare K, Desai V, Li S, Wong J, Luo X, Yu X, Wood L, Wang QM*. Increased Th17/Treg ratio in post-stroke fatigue.Mediators of inflammation, 2015 (June, 2015). Article ID 931396. Wang QM is the corresponding author.
Qin J, Ma X, Qi H, Song B, Wang Y, Wen X, Wang QM, Sun S, Li Y, Zhang R, Liu X, Hou H, Gong G, and Xu Y. Transplantation of induced pluripotent stem cells alleviated cerebral inflammation and neural damage in hemorrhagic stroke. Plos One 2015 June DOI 10.1371
Shi L, Qin J, Song B, Wang QM, Zhang R, Liu X, Liu Y, Hou H, Chen X, Ma X, Jiang C, Sun X, Gong G and Xu Y. Increased frequency of circulating regulatory T cells in patients with acute cerebral hemorrhage. Neuroscience Letter 2015: 591: 115-120.